Séminaire

Mercredi 22 Juin 2022 à 11h00.

Conférence des membres du conseil scientifique du CEFIPRA

'' Attention créneau inhabituel: mercredi 22 juin

1- Title: Quantum Materials by Computation: Challenges & Opportunities
Speaker: Tanusri Saha-Dasgupta
Institution- Department of Condensed Matter Physics & Materials Science, Thematic Unit of Computational Materials Science, S. N. Bose National Centre for Basic Sciences, Kolkata, India

Abstract: In recent times, there has been a worldwide surge of activity in Quantum materials, materials whose properties are dominated by quantum fluctuations, quantum entanglement, quantum coherence, topological behavior. In this talk, I will discuss the contribution of computation in understanding and predicting these materials. In particular, I will discuss its application in understanding materials properties by understanding the structure-property relation, prediction of new functionalities in known materials, and predicting new materials all together.

2- Title: Challenges in tackling the resurgent drug-resistant tuberculosis
Speaker: V. Nagaraja
Institution- Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India

Abstract: Tuberculosis continues to be a global health problem with over nine million new cases added annually and two million deaths every year. The emergence of multiple and total drug resistant strains of Mycobacterium tuberculosis (the bacteria that causes TB) has resulted in worldwide efforts to combat the disease using a variety of strategies. I will describe some of these efforts (including our own) to understand the pathogen biology to develop inhibitors targeted to counter it. By employing a combination of approaches- genetics, molecular and cell biology, and biophysics we have investigated the importance of several essential proteins for the survival mycobacteria. To understand their cellular role, and to target them, we have either developed inhibitors that inhibit bacterial growth or constructed conditional knock down strains to down regulate their expression and disturb cellular function. These genetic and chemical perturbations have revealed hidden secrets of the pathogen’s success facilitating newer intervention strategies.
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